C ells interpret and respond to environmental cues using a signaling network comprising chemical and physical interactions between molecules that, ultimately, modulate cellular behavior. During viral infection, these signaling networks are "hijacked" and rewired by virus proteins in order to induce a state of viral pathogenesis. Our group applies quantitative, systems–level approaches to study signaling aspects of viral infection and develop novel anti-viral therapies. We use genetically–engineered viruses to study viral infection, as well as experimental and computational techniques for monitoring changes in the signaling network induced by these infections. We are currently interested in studying how proteins expressed in early–stage HIV infections establish a pathogenic state in cells of the immune system, and how latent HIV can be reactivated to purge chronic infections.
Kathryn worked previously at the National Academies, Merck Pharmaceuticals, the Chinese Academy of Sciences, and Monitor Group. She received her Ph.D. in Chemical Engineering at MIT with Doug Lauffenburger. and her B.E. & B.A. degrees at Dartmouth College.
She can be reached via either of the following methods:
We have a variety of openings. Interested candidates should contact Professor Miller–Jensen by e–mail.
Graduate students: We have both openings and rotation opportunities for Ph.D. students who have been admitted to the Department of Biomedical Engineering, the Program in Physical and Engineering Biology, or other biology–related disciplines.
Undergraduate students: In order to offer significant and challenging laboratory research projects, we ask undergraduate researchers to commit to 10-15 hours per week for a minimum of 1 year. All majors considered.