Control of stochastic gene expression by host factors at the HIV promoter. Burnett, J.C., Miller-Jensen, K., Shah, P.S.,Arkin, A.P., Schaffer, D.V. PLoS Pathogens 5 (1), 2009.
Cells interpret and respond to environmental cues using a signaling network comprising chemical and physical interactions between molecules that, ultimately, modulate cellular behavior. During viral infection, these signaling networks are "hijacked" and rewired by virus proteins in order to induce a state of viral pathogenesis. Our group applies quantitative, systems–level approaches to study signaling aspects of viral infection and develop novel anti-viral therapies. We use genetically–engineered viruses to study viral infection, as well as experimental and computational techniques for monitoring changes in the signaling network induced by these infections. We are currently interested in studying how proteins expressed in early–stage HIV infections establish a pathogenic state in cells of the immune system, and how latent HIV can be reactivated to purge chronic infections.
About Prof. Miller–Jensen
Kathryn worked previously at the National Academies, Merck Pharmaceuticals, the Chinese Academy of Sciences, and Monitor Group. She received her Ph.D. in Chemical Engineering at MIT with Doug Lauffenburger. and her B.E. & B.A. degrees at Dartmouth College.
She can be reached via either of the following methods:
- phone at (203) 432-4265, or
- e–mail at firstname.lastname@example.org.
We have a variety of openings. Interested candidates should contact Professor Miller–Jensen by e–mail.
Postdoctoral fellows: We are seeking a Postdoctoral Research Associate in computational biology to join our group. The successful candidate will be part of a research collaboration to integrate experimental and computational approaches to study molecular mechanisms underlying the maintenance and reactivation of HIV latency.
Graduate students: We have both openings and rotation opportunities for Ph.D. students who have been admitted to the Department of Biomedical Engineering, the Program in Physical and Engineering Biology, or other biology–related disciplines.
Undergraduate students: In order to offer significant and challenging laboratory research projects, we ask undergraduate researchers to commit to 10-15 hours per week for a minimum of 1 year. All majors considered.
Research Assistant: We are seeking a motivated and independent research assistant to support the development of a microfluidic device to measure cytokine secretion and phosphorylation of intracellular proteins in single cells. The successful candidate will be part of collaboration with Prof. Rong Fan’s research group, with opportunities for co-authorship on resulting publications.
Common effector processing mediates cell-specific responses to stimuli. Miller-Jensen, K.*, Janes, K.A.*, Brugge, J. S., Lauffenburger, D.A. Nature 448 (7153) 604-8, 2007. (Research highlight in Nature Biotechnology, 9/07)
Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. Miller-Jensen, K., Janes, K.A., Wong, Y., Griffith, L.G., Lauffenburger, D.A. J Cell Science 119 (18) 3788-98, 2007. (Research highlight in Nature Biotechnology, 9/07)
Our laboratory is located in the heart of the Yale campus between old campus and Science Hill. You can reach us by phone at (203) 432-4265.
P.O. Box 208260
New Haven, CT 06520
55 Prospect Street
New Haven, CT 06511