C ells interpret and respond to environmental cues using a signaling network comprising chemical and physical interactions between molecules that, ultimately, modulate cellular behavior. Cells maintain reliable cue-signal-response relationships despite significant biological “noise”. When cells are infected by pathogens, we hypothesize that this cell-to-cell variability is important both for mounting an effective immune response by the host and, in some cases, for pathogen evasion of the host’s response. Our group applies quantitative, systems–level experimental and computational approaches to study how intercellular signaling heterogeneity regulates host–pathogen innate immune interactions in macrophages and HIV latency in T cells.
Kathryn worked previously at the National Academies, Merck Pharmaceuticals, the Chinese Academy of Sciences, and Monitor Group. She received her Ph.D. in Chemical Engineering at MIT with Doug Lauffenburger. and her B.E. & B.A. degrees at Dartmouth College.
She can be reached via either of the following methods:
We have a variety of openings. Interested candidates should contact Professor Miller–Jensen by e–mail.
Postdoctoral fellows: We are seeking a full-time Postdoctoral Research Associate to join our interdisciplinary team investigating systems-level regulation of innate immunity. The position is funded in part by pilot grant from the NIH U19 Human Immunology Project Consortium to study the innate immune response to dengue virus infection from macrophage single-cell data, in collaboration with the Montgomery laboratory at the Yale Medical School. Applicants should hold a PhD or MD/PhD in immunology, virology, biology, biomedical engineering, or a related field. Candidates with a background and experimental expertise in immunology are preferred, and those with additional experience in computational data analysis will be given special consideration. The position is available as soon as July 1, 2014. Please send a cover letter, CV, and list of three references as a single PDF.
Graduate students: We have both openings and rotation opportunities for Ph.D. students who have been admitted to the Department of Biomedical Engineering, the Program in Physical and Engineering Biology, or other biology–related disciplines.
Undergraduate students: In order to offer significant and challenging laboratory research projects, we ask undergraduate researchers to commit to 10-15 hours per week for a minimum of 1 year. All majors considered.
Yale University is an Equal Opportunity/Affirmative Action Employer.