C ells interpret and respond to environmental cues using a signaling network comprising chemical and physical interactions between molecules that, ultimately, modulate cellular behavior. Cells maintain reliable cue-signal-response relationships despite significant biological “noise”. When cells are infected by pathogens, we hypothesize that this cell-to-cell variability is important both for mounting an effective immune response by the host and, in some cases, for pathogen evasion of the host’s response. Our group applies quantitative, systems–level experimental and computational approaches to study how intercellular signaling heterogeneity regulates host–pathogen innate immune interactions in macrophages and HIV latency in T cells.
Kathryn worked previously at the National Academies, Merck Pharmaceuticals, the Chinese Academy of Sciences, and Monitor Group. She received her Ph.D. in Chemical Engineering at MIT with Doug Lauffenburger. and her B.E. & B.A. degrees at Dartmouth College.
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Qiong's and Yao's paper is published in Science Signaling. Qiong and Yao compared data from isolated single-cell assays to data from populations of cells to demonstrate that paracrine signaling is essential for stimulating a full LPS secretion response. . Posted 2015-06-16
Linda, Victor, and Arvind present posters at the Keystone HIV conference in Boston. Linda, Victor, and Arvind presented posters at the recent Keystone conference, Mechanisms of HIV Persistence: Implications for a Cure. Posted 2015-04-26
Victor Bass (MCDB student) joined our lab. Welcome, Victor!. Posted 2015-03-06
Kathryn receives National Science Foundation career award. Kathryn was selected to receive the 2015 NSF CAREER Award for our group's project, "Reverse Engineering the Inflammatory Signaling Network from Single-Cell Data." The award provides $500,000 in funding to researchers who exemplify the role of teacher-scholars. The CAREER Award is the NSF’s most prestigious award for junior faculty. Posted 2015-02-06
Kathryn receives the 2014 Ackerman Award for Teaching and Mentoring. Kathryn was selected to receive the 2014 Ackerman Award for Teaching and Mentoring. . Posted 2014-05-06