Latest news from the Miller-Jensen lab at Yale

Ramesh's device is in the news. Ramesh's device is featured in [SciTechDaily] (http://scitechdaily.com/researchers-develop-a-new-device-for-studying-changes-in-t-cells/) . Posted 2015-07-15

Ramesh, Victor, and Arvind's paper is published in Integrative Biology. Ramesh designed a simple microfluidic device to trap an array of single T cells and then they used it to image noisy activation of latent HIV. Posted 2015-06-28

*Qiong's and Yao's paper is published in Science Signaling *. Qiong and Yao compared data from isolated single-cell assays to data from populations of cells to demonstrate that paracrine signaling is essential for stimulating a full LPS secretion response in macrophages. Markus applied data-driven modeling of the single-cell data to identify the most crucial paracrine signals regulating the response. . Posted 2015-06-16

Linda, Victor, and Arvind present posters at the Keystone HIV conference in Boston. Linda, Victor, and Arvind presented posters at the recent Keystone conference, Mechanisms of HIV Persistence: Implications for a Cure. Posted 2015-04-26

Victor Bass (MCDB student) joined our lab. Welcome, Victor!. Posted 2015-03-06

Kathryn receives National Science Foundation career award. Kathryn was selected to receive the 2015 NSF CAREER Award for our group's project, "Reverse Engineering the Inflammatory Signaling Network from Single-Cell Data." The award provides $500,000 in funding to researchers who exemplify the role of teacher-scholars. The CAREER Award is the NSF’s most prestigious award for junior faculty.

This project examines why genetically identical macrophages — the first responders in the immune system — vary in how strongly they respond to the presence of pathogens by secreting pro-inflammatory "danger signals." Using state-of-the-art experimental tools for single-cell analysis, our group is identifying the sources of heterogeneity from transcription to secretion of proteins used for intracellular communication. These experiments are used to fit a mathematical model of signaling, cytokine secretion, and diffusion fit to single-cell data so that we can make predictions about emergent population behavior. Posted 2015-02-06

Kathryn receives the 2014 Ackerman Award for Teaching and Mentoring. Kathryn was selected to receive the 2014 Ackerman Award for Teaching and Mentoring. Each year the awardee is chosen by an appointed student selection committee based on nominations received from both current SEAS students as well as recent SEAS alumni. Posted 2014-05-06