Latest news from the Miller-Jensen lab at Yale

Congrats, Dr. Muñoz-Rojas. Andrés successfully defended his thesis, "Analysis of macrophage polarization: single-cell responses in controlled and tumor microenvironments". Congrats!. Posted 2018-03-23

Congrats, Dr. Fong. Linda successfully defended her thesis, "Data-Driven Analysis of Phospho-Signaling Network Responses Enables Latent HIV-Infected T Cell Targeting". Congrats!. Posted 2017-11-20

Elise is awarded a PEB Training grant slot. Elise Bullock was awarded a slot on Yale's NIH T32 Training grant supporting the Integrated Graduate Program in Physical and Engineering Biology. Posted 2017-06-08

Amanda is awarded an NSF Grad Student Fellowship. Amanda Alexander was awarded a Graduate Student Research Fellowship from the National Science Foundation. Posted 2016-04-05

Ramesh's device is in the news. Ramesh's device is featured in [SciTechDaily] ( . Posted 2015-07-15

Ramesh, Victor, and Arvind's paper is published in Integrative Biology. Ramesh designed a simple microfluidic device to trap an array of single T cells and then they used it to image noisy activation of latent HIV. Posted 2015-06-28

Qiong's and Yao's paper is published in Science Signaling. Qiong and Yao compared data from isolated single-cell assays to data from populations of cells to demonstrate that paracrine signaling is essential for stimulating a full LPS secretion response in macrophages. Markus applied data-driven modeling of the single-cell data to identify the most crucial paracrine signals regulating the response. . Posted 2015-06-16

Linda, Victor, and Arvind present posters at the Keystone HIV conference in Boston. Linda, Victor, and Arvind presented posters at the recent Keystone conference, Mechanisms of HIV Persistence: Implications for a Cure. Posted 2015-04-26

Victor Bass (MCDB student) joined our lab. Welcome, Victor!. Posted 2015-03-06

Kathryn receives National Science Foundation career award. Kathryn was selected to receive the 2015 NSF CAREER Award for our group's project, "Reverse Engineering the Inflammatory Signaling Network from Single-Cell Data." The award provides $500,000 in funding to researchers who exemplify the role of teacher-scholars. The CAREER Award is the NSF’s most prestigious award for junior faculty.

This project examines why genetically identical macrophages — the first responders in the immune system — vary in how strongly they respond to the presence of pathogens by secreting pro-inflammatory "danger signals." Using state-of-the-art experimental tools for single-cell analysis, our group is identifying the sources of heterogeneity from transcription to secretion of proteins used for intracellular communication. These experiments are used to fit a mathematical model of signaling, cytokine secretion, and diffusion fit to single-cell data so that we can make predictions about emergent population behavior. Posted 2015-02-06