Latest news about the Miller-Jensen lab

Kathryn Speaks at U of British Columbia

Kathryn gave the SBME Seminar at the University of British Columbia, School of Biomedical Engineering (Vancouver Campus). She spoke about our work on single-cell analysis of macrophage heterogeneity.

Congrats, Dr. Muñoz-Rojas!

Andrés successfully defended his thesis, “Analysis of macrophage polarization: single-cell responses in controlled and tumor microenvironments”. Congrats!

Linda Fong Defends

Linda successfully defended her thesis, “Data-Driven Analysis of Phospho-Signaling Network Responses Enables Latent HIV-Infected T Cell Targeting”. Congrats!

Elise is awarded a PEB Training grant

Elise Bullock was awarded a slot on Yale’s NIH T32 Training grant supporting the Integrated Graduate Program in Physical and Engineering Biology.

Kathryn Receives Nsf Career Award

Kathryn was selected to receive the 2015 NSF CAREER Award for our group’s project, “Reverse Engineering the Inflammatory Signaling Network from Single-Cell Data.” The award provides $500,000 in funding to researchers who exemplify the role of teacher-scholars. The CAREER Award is the NSF’s most prestigious award for junior faculty.

This project examines why genetically identical macrophages — the first responders in the immune system — vary in how strongly they respond to the presence of pathogens by secreting pro-inflammatory “danger signals.” Using state-of-the-art experimental tools for single-cell analysis, our group is identifying the sources of heterogeneity from transcription to secretion of proteins used for intracellular communication. These experiments are used to fit a mathematical model of signaling, cytokine secretion, and diffusion fit to single-cell data so that we can make predictions about emergent population behavior.